Neuroendocrine transduction of social-economicpolitical-emotional (sepe) factors that regulate human skeletal growth

Bogin, Barry
Loughborough University, Loughborough, United Kingdom of Great Britain and Northern Ireland

Abstract: There is renewed research focus on the regulation of human growth via biocultural interactions between community networks and hormonal physiology. Human communities are networks of Social-EconomicPolitical-Emotional (SEPE) factors. SEPE factors can enhance or diminish feelings of love and hope, which in turn can promote or delay skeletal growth. This presentation extends previous research (DOI: 10.1186/s40101-023-00330-7) on the physiology of the SEPE factors ‘love and hope’. The scientific study of love and hope is possible via pathways that transduce Social-Economic-Political factors that structure human communities into Emotional factors (the SEPE infrastructure). There are several neuroendocrine pathways by which love and hope create measurable hormonal substances that regulate skeletal growth: 1) the hypothalamic-growth hormone-insulin-like growth factor-I pathway; 2) the hypothalamic-adrenalstress hormone pathway; 3) the stress hormone–osteocalcin pathway; 4) the hypothalamic-oxytocin-bone formation pathway. Human examples of neuroendocrine transduction from love, hope, and other SEPE factors to skeletal growth regulation are: 1) civil war in Guatemala, 2) international migration, 3) the 2008 banking crisis, and 4) winner-loser effects in status competition.